ABSTRACT
Aims: To estimate the prognostic value of tumor-infiltrating lymphocytes, among other variables, in triple-negative breast cancer patients with a 17-year disease-free survival. Study Design: A retrospective study of 79 patients was conducted to investigate treatment, and clinical, microscopic and immunohistochemical tumor characteristics. Place and Duration of Study: Pathology Division, National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil, between January 1992 and December 1996. Methodology: Histologically diagnosed 79 node-negative triple-negative breast cancer patients underwent partial or total mastectomy with axillary lymphadenectomy, with or without radiotherapy, chemotherapy and/or hormone therapy. Disease-free survival was estimate by the Kaplan-Meier method and log-rank test. Prognostic variables were obtained by Cox regression models. Results: The 17-year disease-free survival was 50.6%. Disease-free survival was worse in patients aged 51-82 years, who underwent neoadjuvant chemotherapy and had skin compromise, geographic necrosis, grade 3 tumors, had no tumor-infiltrating lymphocytes, had vascular/lymphatic invasion, CD44+/CD24-/low and elevated Ki-67. The risk of recurrence and/or metastasis, adjusted for the remaining variables of the final Cox model was 2.44 times higher for patients aged 51-82 years, 2.60 times higher for patients undergoing neoadjuvant chemotherapy, 3.97 times higher for grade 3 tumors and 0.34 times for patients with tumor-infiltrating lymphocytes. Conclusion: The risk of recurrence and/or metastasis, adjusted for the remaining variables of the model, was about 2.5 times higher for older patients undergoing neoadjuvant chemotherapy. In grade 3 tumor patients, the risk increased almost fourfold. Patients with tumor-infiltrating lymphocytes had a 66% lower risk, i.e, tumor-infiltrating lymphocytes were shown to be a protective factor.